Heart rate lowering reduces cardiovascular disease burden
نویسندگان
چکیده
منابع مشابه
Potential interests of heart rate lowering drugs.
Epidemiological studies have shown that a high heart rate at rest is a risk factor for global and cardiovascular mortality. 1–3 A rapid heart rate is associated with a variety of prognostic factors indicative of worse heart conditions (for example , hypoxaemia, anaemia, alcohol consumption , low physical training status). The link between a high resting heart rate and an increase in overall and...
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Ivabradine, an I(f) inhibitor, acts primarily on the sinoatrial node and is used to reduce the heart rate with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. Heart rate reduction is an important aspect of care in patients with chronic stable angina and heart failure. Many patients with coronary artery disease have coexisting asthma or chronic obstructiv...
متن کاملPrognostic value of heart rate in cardiovascular disease.
Background Those animals that live longer tend to have slower heart rates (HR). Several plausible theories suggest that this may not be a chance association but that the slower heart rate may have a causal relationship to longer life. Accordingly, a large number of cohort studies in the past years have tried to establish whether HR measurement may portend significant prognostic implications in ...
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The funny or hyperpolarization-activated cyclic nucleotide-gated channel (HCN) modulates cardiac excitability and heart rate by regulating the If or IKf current in sinoatrial cells. The 4 HCN channel isoforms (HCN1–4) are unique in that they are activated by both cyclic adenosine monophosphate (AMP) and hyperpolarized membrane channels. Thus, sympathetic activation of b-adrenergic receptors (b-...
متن کاملLowering of the Heart Rate in Massive Pericardial Effusion
E LECTRICAL ALTERNANS is characteristic of pericardial effusion, especially of neoplastic origin. This phenomenon has been explained by increased cardiac motion or rotation due to the excessive fluid in the pericardium.' This assumption has been supported by studies employing reflected ultrasound.2 In addition to the excessive motion of the heart, rapid heart rate has been considered a critical...
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ژورنال
عنوان ژورنال: Current Medical Research and Opinion
سال: 2014
ISSN: 0300-7995,1473-4877
DOI: 10.1185/03007995.2014.922945